Michele Migliore's lab

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Academic and Scientific activity

We are interested in understanding how the brain works. For this purpose, we use the available experimental data to design, implement and analyze realistic models of neurons, synapses, and networks. The goal is to uncover the mechanisms underlying higher brain functions, to help the development of innovative therapies to treat brain diseases and dysfunctions. The list of scientific publications will give you an idea of how we do that.
The course on Computational Neuroscience (#1055858) at the Department of Neurobiology of the University of Rome "La Sapienza" will begin Wednesday Oct.7th 2020. Class schedule: 09:00-13:00, every Wed, and Thurs. until Nov.26th. Students interested in taking the course are kindly invited to contact Michele Migliore. More info on the course can be found here .

International Collaborations

Logo of the University of Yale
Yale University School of Medicine
Department of Neuroscience
P.O. Box 208001, New Haven, CT 06520-8001, USA
Logo of the University of Naples
University of Naples Federico II
Department of Mathematics
via Cintia, Naples, Italy
Logo of the University of Naples
University of Naples Federico II
Department of Neuroscience
via Pansini 5, 80131 Naples, Italy
Logo of the Heinrich Heine University
Heinrich Heine University
Department of Neuro- and Sensory Physiology
Universitätsstraße 1, 40225 Düsseldorf, Germany
Logo of the European Brain Research Institute
European Brain Research Institute
via del Fosso di Fiorano 64, 00143 Rome, Italy
Logo of the University of Palermo
University of Palermo
Department of Mathematics and Computer Science
via Archirafi, Palermo, Italy
Logo of the CNRS
UMR7275, Valbonne, France
Logo of the Otto-von-Guericke-University
Otto-von-Guericke-University Magdeburg
Institute of Physiology
Leipziger Str. 44, Haus 28 39120 Magdeburg, Germany

External Funding

Human Brain Project logo
The Human Brain Project (HBP) is a European Commission Future and Emerging Technologies Flagship. The HBP aims to put in place a cutting-edge, ICT-based scientific Research Infrastructure for brain research, cognitive neuroscience and brain-inspired computing. The Project promotes collaboration across the globe, and is committed to driving forward European industry.
The CircProt project focuses on synaptic circuit protection in Alzheimers’s disease (AD) and Hunting-tion’s disease (HD). Alzheimer’s and Huntington’s disease result from the erroneous communication of neurons at synapses in different brain areas (neocortex, hippocampus, striatum). The protein BDNF regulates synaptic communication under healthy conditions. However, insufficient release of BDNF from neurons and defective BDNF signaling in target neurons contribute to cellular malfunctions in AD and HD. Although they are essential to the development of effective therapies, the underlying molecular mechanisms for deficits in synaptic communication in these diseases are not understood.